Eristostatin


Organism:Eristicophis macmahoni
Taxonomy:
Uniprot ID:P0C6S4
PDB ID:
Mass:5,511
Length:49
Sequence:P0C6S4.fasta


LigandActivitiesIC50Cell linesReferences
VCAM-1, VEGF-A, OPN, Tenascin-C, angiostatin, tTG, factor XIIIA potent inhibitor of ADP-induced platelet aggregation. A potent inhibitor of human and murine melanoma metastases in mouse model systems, also due to the inhibition of binding between the alpha-4/beta-1 integrin and the vascular cell adhesion protein VCAM1. Inhibits cell migration on fibronectin, but not that on collagen IV or laminin. 7-8 Nmmouse model systemsPMID:7641809 PMID: 8042985 PMID: 7538018 PMID: 9457071 PMID: 7549046 PMID: 17316731