Bisba-01


Organism:Bothrops alternatus
Taxonomy:
Uniprot ID:Q801Z4
PDB ID:
Mass:8,236
Length:78
Sequence:Q801Z4.fasta


LigandActivitiesIC50Cell linesReferences
fibronectin, vitronectin, fibrinogen, VWF, TSPInhibits platelet aggregation induced by ADP, thrombin, and collagen, abolishes and reverses dynamic platelet recruitment to immobilized fibrinogen. Inhibits the adhesion of ITGAV/ITGB3-expressing human microvascular endothelial cell line and murine melanoma cell line to vitronectin. Inhibits their proliferation without direct cell toxicity, Inhibits tumor cell migration in vitro 555 nM and 225 NmHuman microvascular endothelial cell line and murine melanoma cell line PMID: 17952617 PMID : 18508682 PMCID: PMC3153172 PMID: 22561350